Therapeutic Areas
Thrombosis and Hemostasis (Platelets)
- Activation (CD62(P-selectin), CD63, CD40L, PAC-1)
- Adhesion (Static and Dynamic)
- Agglutination
- Aggregation (PRP* and Whole Blood)
- Angiogenic factors
- Anti-Platelet Antibody Detection
- Clot retraction (Whole Blood and PRP)
- Clot strength (TEG Platelet Mapping*)
- Counts/MPV
- Immature Platelet Function
- Microfluidics
- Non-human ex vivo testing
- Platelet Surface Proteins
- Platelet-Leukocyte Aggregates
- Point-of-Care Testing including VerifyNow
- Procoagulant Function
- Secretion (PF4; Lumi-aggregometry)
- VASP* and other Phosphoproteins
Coagulation
- Activated Clotting Time (ACT)
- Activated Partial Thromboplastin Time (aPTT)
- Antithrombin (ATIII)
- Anti-Xa**
- Coagulation Factor ** (levels/activities)
- D-dimer*
- Fibrinogen**
- Free Tissue factor Pathway Inhibitor (fTFPI)**
- Halo (thrombolysis) Assay
- t-PA
- PF4*
- Plasmin-Antiplasmin Complex (PAP)**
- Protein C
- Protein S
- Prothrombin Fragment 1.2 (PF1.2*)
- Prothrombin Time (PT)*
- Reversal Agent MOA and Interference Testing
- Russell Viper Venom Test (RVVT)**
- Soluble Thrombomodulin (sTM)**
- Thrombin Activatable Fibrinolytic Inhibitor (TAFI)**
- Thrombin-Antithrombin Complexes (TAT)*
- Thrombin Generation*
- Thromboelastography (TEG Platelet Mapping*) and Fibrinogen*
- b-Thromboglobulin (b-TG)*
- Tissue Factor (TF)
- Tissue Factor Pathway Inhibitor (TFPI) Activity**
- Tissue Plasminogen Activator (tPA)**
- vWF
- WBCT
Oncology
- 3-D Tissue Culture
- Biomarkers (cytokines, chemokine, MMPs, CD Antigens, MPs, Bcl-2, Caspase-3, cleaved PARP, p53, GAPDH, Cytochrome c, PD-1, TRAIL, etc.)
- Biosimilars
- Cancer cell-Platelet Interactions (static and microfluidic assays)
- Cell Adhesion, Migration and Invasion Assays
- Complete Histopathology Analysis (tissue biomarkers) ***
- Epigenetic Study Support (methylated DNA and miRNAs arrays)
- Flow Cytometry (antigen detection, monoclonal antibody binding, ligand occupancy, absolute cell counts, cell signaling pathways, DNA analysis, immunophenotyping,)
- Genetic Variation and Mutation Assays
- Genome-wide Microarrays***
- Immunoprecipitations, SDS/PAGE, Western blot
- Next Generation Sequencing***
- qRT-PCR
- Viral Load Assessment
Cardiology and Heart Failure
- BNP, NT-pro-BNP,
- GDF-15, Galectin-3, -9, Copeptin, Cystatin C, sT2
- miRNA
- MR-proANP, MR-proADM
- MMP 1-13
- TIMPs
- CRP
- TnI, TnT, CKMB
Hematology
- ADAMTS 13 (levels, activity)
- Coagulopathies
- Coombs Test
- Erythrocytes: Hemolysis, Complement Activation
- Granulocytes: Antigen Expression (e.g. Mac-1), Oxidative Burst, Platelet-Granulocyte Aggregates
- Hematologic Malignancies (functional and phenotyping)
- Immunogenicity
- Monocytes: CD Antigens Expression, Migration, Platelet-Monocyte Aggregates
- PECAM-1
- Platelet Abnormalities (B-S, GT, Release defect, Storage Pool Disease) and Dysfunction
- Thrombopoietin (TPO)
Vascular Bed Diseases / Thrombic Microangiopathies
- Cell Proliferation, Adhesion, Apoptosis
- Circulating Endothelial Cells
- Homocysteine**
- Hyaluronan**
- L-ficolin**
- LOX-1
- Lp-PLA2
- Microparticles
- CRP
- MCP-1
- S100B
- Proinflammatory biomarker panels
- Receptor and Co-receptors (e.g., CD14)
- Soluble CAMs, selectins, growth factors, cytokine panels
Key
* FDA compliant validated tests
** Client-directed validated tests
*** Qualified 3rd party vendor